Potent tankyrase inhibitor
WIKI4 is an inhibitor of Wnt/β-catenin signaling (EC50 ∼ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ∼15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).
WIKI4 synthesized to Ancillary Material Grade also available.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-151694 |
| Réf. fabricant | 18798446 |
| Nom chimique ou matériau | 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione |
| CAS | 838818-26-1 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>29</sub>H<sub>23</sub>N<sub>5</sub>O<sub>3</sub>S |
| Poids de la formule | Observed MW: 521.59 |
