Potent and selective GPR171 partial agonist
MS 15203 is a potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of Forskolin activated adenylyl cyclase activity in rat hypothalamic membranes). Exhibits minimal binding to a panel of ∼70 GPCRs and 10 other receptors (<22% of radioligand displaced from the target receptors). Increases neuronal activity in the paraventricular nucleus. Increases food intake and body weight in mice.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-151791 |
| Réf. fabricant | 18799748 |
| Nom chimique ou matériau | 5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicarboxylic acid |
| CAS | 73912-52-4 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>12</sub>H<sub>11</sub>NO<sub>5</sub> |
| Poids de la formule | Observed MW: 249.22 |
