Potent S1P receptor agonist; also immunosuppressant
FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ∼3 nM for S1P3). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an
in vivo
model of MS). Orally bioavailable and blood-brain barrier permeable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-152014 |
| Réf. fabricant | 18792168 |
| Type de produit | Agonist |
| Protéines cibles | Sphingosine-1-phosphate Receptor |
| CAS | 162359-56-0 |
| Formule moléculaire | C<sub>19</sub>H<sub>33</sub>NO<sub>2</sub>.HCl |
| Poids de la formule | 343.93g/mol |
| Synonyme | Fingolimod, Gilenya |
| Contenu et stockage | Store at -20°C |
| À utiliser avec (application) | Sphingosine-1-phosphate Receptor Agonists |
| Quantité | 10 mg |
