"/> Tocris Bioscience™ TM 38837 | B-LABO France

Tocris Bioscience™ TM 38837

Réf. : BL-RE-157967Réf. fabricant : 18795346 5 mg
277,53 € HT

Highly potent CB1 inverse agonist; peripherally restricted

Nom chimique ou matériau
1-(2,4-Dichlorophenyl)-4-ethyl-N-1-piperidinyl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1 H-pyrazole-3-carboxamide
CAS
1253641-65-4
Quantité
5 mg
Cible
Cannabinoid R1 / CB1 Inverse Agonists
Formule moléculaire
C30H25Cl2F3N4OS
Marque
Tocris Bioscience

TM 38837 is a highly potent cannabinoid 1 receptor (CB1) inverse agonist (IC50 values are 8.5 nM and 605 nM for inhibition of [3H]-CP 55940 binding at CB1 and CB2 receptors, respectively). Displays 71-fold selectivity for CB1 receptors over CB2 receptors. Inhibits GTP binding to CB1-overexpressing cell membranes

in vitro

(EC50 = 18.5 nM). Peripherally restricted. Promotes fear behaviors when given by intracerebrovascular (icv) injection in mice.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-157967
Réf. fabricant18795346
Nom chimique ou matériau1-(2,4-Dichlorophenyl)-4-ethyl-N-1-piperidinyl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1 H-pyrazole-3-carboxamide
CAS1253641-65-4
Quantité5 mg
CibleCannabinoid R1 / CB1 Inverse Agonists
Formule moléculaireC<sub>30</sub>H<sub>25</sub>Cl<sub>2</sub>F<sub>3</sub>N<sub>4</sub>OS
Pureté0.98
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