Potent and selective herpes simplex virus (HSV) helicase primase inhibitor
Pritelivir is a potent and selective herpes simplex virus (HSV) helicase primase inhibitor. Pritelivir inhibits viral replication in Vero cells (IC50 = 0.02 μM for HSV-1 and HSV-2). It also reduces β-amyloid and P-tau levels in Vero cells. Pritelivir is active against clinical isolates and porcine and bovine HSV strains but displays reduced activity against varicella zoster virus and cytomegalovirus
in vitro
. In addition, the compound exhibits antiviral activity in HSV infected mice.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-157984 |
| Réf. fabricant | 18715666 |
| Nom chimique ou matériau | N-[5-(Aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)benzeneacetamide |
| CAS | 348086-71-5 |
| Quantité | 50 mg |
| Cible | Antiviral Compounds |
| Formule moléculaire | C<sub>18</sub>H<sub>18</sub>N<sub>4</sub>O<sub>3</sub>S<sub>2</sub> |
| Pureté | 0.98 |
