Selective exportin 1 (XPO1/CRM1) inhibitor
Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter. Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC50 values are 11-550 nM and >1000 nM, respectively), and reduces growth of xenografts. Inhibits growth of thyroid cancer cell lines (IC50 = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat. No. 7579) in ovarian cancer and breast cancer. Also a potent inhibitor of SARS-CoV-2 replication
in vitro
(EC50 = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF-α and IL-6.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-157989 |
| Réf. fabricant | 18737176 |
| Nom chimique ou matériau | (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide |
| CAS | 1393477-72-9 |
| Quantité | 10 mg |
| Cible | Antiviral Compounds |
| Formule moléculaire | C<sub>17</sub>H<sub>11</sub>F<sub>6</sub>N<sub>7</sub>O |
