"/> Tocris Bioscience™ SGC SMARCA-BRDVIII | B-LABO France

Tocris Bioscience™ SGC SMARCA-BRDVIII

Réf. : BL-RE-158042Réf. fabricant : 18796906 50 mg
680,33 € HT

Potent and selective SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomain inhibitor

Nom chimique ou matériau
1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains
CAS
1997319-84-2
Quantité
50 mg
Cible
Bromodomain Inhibitors
Formule moléculaire
C19H25N5O3
Marque
Tocris Bioscience

SGC-SMARCA-BRDVIII is a selective and high affinity SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomains (Kd(ITC) values are 35, 36 and 13 nM, respectively). SGC-SMARCA-BRDVIII exhibits selectivity over 25 other bromodomain families and shows no off-target activity on 85 protein kinases screened using temperature-shift binding assays. SGC-SMARCA-BRDVIII suppresses formation of 3T3-L1 mouse fibroblasts into adipocytes (EC50 <1.0 μM).

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-158042
Réf. fabricant18796906
Nom chimique ou matériau1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains
CAS1997319-84-2
Quantité50 mg
CibleBromodomain Inhibitors
Formule moléculaireC<sub>19</sub>H<sub>25</sub>N<sub>5</sub>O<sub>3</sub>
Pureté0.98
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