"/> Tocris Bioscience™ Tucatinib | B-LABO France

Tocris Bioscience™ Tucatinib

Name: Tocris Bioscience™ Tucatinib
Brand: Tocris Bioscience
SKU: 18725896
Price: 764.56 EUR
Availability: InStock

Réf. : BL-RE-158094Réf. fabricant : 18725896 50 mg

764,56 € HT

Potent and selective ErbB2 inhibitor

Nom chimique ou matériau: N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4 ]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine
CAS: 937263-43-9
Quantité: 50 mg
Cible: EGF Receptor Inhibitors
Formule moléculaire: C₂₆H₂₄N₈O₂
Marque: Tocris Bioscience

Tucatinib is a potent and selective ErbB-2 (also called HER2) kinase inhibitor (IC50 = 7 nM). It exhibits >50-fold selectivity for ErbB-2 over EGFR.

In vitro

, Tucatinib inhibits ErbB-2 signaling activity and cell proliferation in ErbB-2-amplified breast cancer cell lines (BT-474).

In vivo

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-158094
Réf. fabricant	18725896
Nom chimique ou matériau	N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4 ]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine
CAS	937263-43-9
Quantité	50 mg
Cible	EGF Receptor Inhibitors
Formule moléculaire	C<sub>26</sub>H<sub>24</sub>N<sub>8</sub>O<sub>2</sub>
Pureté	0.98

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