SR 10067 is a selective Rev-Erbα/β agonist (IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα respectively). Exhibits no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM. Increases wakefulness, reduces REM and slow wave sleep
in vivo
. Also reduces anxiety-like behavior in marble-burying assay. Cell permeable and brain penetrant.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-158105 |
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| Réf. fabricant | 18707988 |
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| Nom chimique ou matériau | [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone |
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| CAS | 1380548-02-6 |
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| Plage de pourcentage du dosage | >98% |
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| Quantité | 50 mg |
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| Formule moléculaire | C<sub>31</sub>H<sub>31</sub>NO<sub>3</sub> |
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| Poids de la formule | Observed MW: 465.58 |
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