Potent farnesyl diphosphate (FPP) synthase inhibitor
Zoledronic Acid is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-158114 |
| Réf. fabricant | 18720109 |
| Nom chimique ou matériau | Ras GTPase Inhibitors |
| CAS | 118072-93-8 |
| Synonyme | [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid |
| Quantité | 50 mg |
| Solubilité | Soluble to 50mM in 1.1eq. NaOH and to 3mM in water |
| Formule moléculaire | C<sub>5</sub>H<sub>10</sub>N<sub>2</sub>O<sub>7</sub>P<sub>2</sub> |
| Poids de la formule | 272.09 |
| Forme physique | Solid |
| Couleur | Off-white |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
