Go 6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC
in vitro
; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-158136 |
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| Réf. fabricant | 18094722 |
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| Nom chimique ou matériau | 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile |
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| CAS | 136194-77-9 |
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| Quantité | 500 μg |
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| Cible | Protein Kinase C Inhibitors |
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| Formule moléculaire | C<sub>24</sub>H<sub>18</sub>N<sub>4</sub>O |
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| Pureté | 95% |
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