Potent, selective VEGFR-2 inhibitor
Ki 8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth
in vivo
; antiangiogenic.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-158141 |
| Réf. fabricant | 18004702 |
| Nom chimique ou matériau | N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea |
| CAS | 228559-41-9 |
| Plage de pourcentage du dosage | >97% |
| Quantité | 50 mg |
| Solubilité | Soluble to 100mM in DMSO |
| Formule moléculaire | C<sub>24</sub>H<sub>18</sub>F<sub>3</sub>N<sub>3</sub>O<sub>4</sub> |
| Poids de la formule | Observed MW: 469.41 |
