"/> Tocris Bioscience™ HER2 PROTAC™ CH7C4 | B-LABO France

Tocris Bioscience™ HER2 PROTAC™ CH7C4

Réf. : BL-RE-158170Réf. fabricant : 18095662 5 mg
357,45 € HT

Potent and selective HER2 targeting PROTAC™

Nom chimique ou matériau
5-((7-(4-(3-((4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperazin-1-yl)heptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Quantité
5 mg
Cible
Active Degraders
Formule moléculaire
C49H55N11O7
Pureté
98%
Marque
Tocris Bioscience

HER2 PROTAC™ CH7C4 is a potent and selective HER2 (also called ErbB-2) targeting PROTAC™ (DC50 = 69 nM; Dmax = 96%). Inhibits BT-474 cell proliferation (IC50 = 47 nM) and xenograft growth. Comprises a Tucatinib (Cat. No. 7640) analog, joined by a linker to a CRBN E3 ligase ligand.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-158170
Réf. fabricant18095662
Nom chimique ou matériau5-((7-(4-(3-((4-((4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)amino)-6-methoxyquinazolin-7-yl)oxy)propyl)piperazin-1-yl)heptyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Quantité5 mg
CibleActive Degraders
Formule moléculaireC<sub>49</sub>H<sub>55</sub>N<sub>11</sub>O<sub>7</sub>
Pureté98%
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