AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). Reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells
in vitro
.
Caractéristiques techniques
| Marque | Tocris |
|---|
| Réf. B-LABO | BL-RE-160704 |
|---|
| Réf. fabricant | 18707116 |
|---|
| CAS | 2093408-03-6 |
|---|
| Quantité | 1 mg |
|---|
| Cible | Protease-Activated Receptor Agonists |
|---|
| Formule moléculaire | C<sub>30</sub>H<sub>49</sub>N<sub>9</sub>O<sub>6</sub> |
|---|
| Pureté | 0.95 |
|---|
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