CP 122721 hydrochloride is a high affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active
in vivo
.
Caractéristiques techniques
| Marque | Tocris Bioscience |
|---|
| Réf. B-LABO | BL-RE-160714 |
|---|
| Réf. fabricant | 18758758 |
|---|
| CAS | 145877-52-7 |
|---|
| Synonyme | (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride |
|---|
| Quantité | 5 mg |
|---|
| Formule moléculaire | C<sub>20</sub>H<sub>23</sub>F<sub>3</sub>N<sub>2</sub>O<sub>2</sub>.2HCl |
|---|
| Poids de la formule | 453.33 |
|---|
| Pureté | 98% |
|---|
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