γ-secretase inhibitor; induces neuronal differentiation
Compound E is a γ-secretase and notch patchway inhibitor. Compound E enhances growth inhibition, differentiation and migration of neuroblastoma cells when used in a combination with DAPT (Cat. No. 2634) and 13-cis RA. In combination with hLIF, CHIR 99021 (Cat. No. 4423) and SB 431542 (Cat. No. 1614), Compound E accelerates the induction of a homogeneous, self-renewing primitive neuroepithelium population from hESCs. Compound E is active in vitro and in vivo.
For more information about how Compound E may be used, see our protocol:
Generation of β cells from hPSCs
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-160721 |
| Réf. fabricant | 18776179 |
| Nom chimique ou matériau | N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| CAS | 209986-17-4 |
| Quantité | 1 mg |
| Formule moléculaire | C<sub>27</sub>H<sub>24</sub>F<sub>2</sub>N<sub>4</sub>O<sub>3</sub> |
| Pureté | 98% |
