Selective STING Degrader (PROTAC™)
STING Degrader SP23 is a selective stimulator of interferon gene (STING) Degrader (PROTAC™; DC50 = 3.2 μM). Comprises the STING inhibitor (C-170), joined by a linker to a CRBN ligand Pomalidomide (Cat. No. 6302). It does not degrade JAK2, STAT3, PI3K, AKT and TLR4 in THP-1 cells. STING Degrader SP23 dose dependently reduces the levels of IFN-β, IL-6, and CXCL10 triggered by cGAMP in THP-1 cells; it also modulates the downstream signals of the STING signaling pathway
in vivo
. STING Degrader SP23 has high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model.
Negative control STING Degrader N-Me-SP23 (Cat. No. 8054) also available.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-160728 |
| Réf. fabricant | 30000414 |
| Nom chimique ou matériau | (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide |
| CAS | 2762552-74-7 |
| Quantité | 5 mg |
| Cible | Active Degraders |
| Formule moléculaire | C<sub>34</sub>H<sub>33</sub>N<sub>7</sub>O<sub>10</sub> |
| Pureté | 98% |
