Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
FK 866 is a non-competitive and high-affinity inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by Etoposide (Cat. No. 1226) and Cisplatin (Cat. No. 2251).
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-160733 |
| Réf. fabricant | 30000441 |
| Nom chimique ou matériau | (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide |
| CAS | 658084-64-1 |
| Quantité | 10 mg |
| Cible | NAMPT Inhibitors |
| Formule moléculaire | C<sub>24</sub>H<sub>29</sub>N<sub>3</sub>O<sub>2</sub> |
| Pureté | 98% |
