ML 323 is a potent and selective allosteric inhibitor of USP1-UAF1 deubiquitinase complex (IC50 = 76 nM). Exhibits selectivity for USP1-UAF1 over a panel of enzymes, including other deuquitinating enzymes. Inhibits deubiquitination of PCNA and FANCD2 and sensitizes cisplatin-resistant H596 cells to cell death induced by cisplatin (Cat. No. 2251)
in vitro
.
Caractéristiques techniques
| Marque | Tocris Bioscience |
|---|
| Réf. B-LABO | BL-RE-160738 |
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| Réf. fabricant | 18781408 |
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| CAS | 1572414-83-5 |
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| Synonyme | 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine |
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| Quantité | 5 mg |
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| Formule moléculaire | C<sub>23</sub>H<sub>24</sub>N<sub>6</sub> |
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| Poids de la formule | 384.48 |
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| Pureté | 98% |
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