Positive allosteric modulator of α7 nAChRs; analgesic
B 973B is a positive allosteric modulator of α7 nAChRs (EC50 ∽0.3 μM); active enantiomer. Increases potency of acetylcholine (EC50 values are 0.007 mM and 0.3 mM in the presence and absence of B 937B, respectively). Potentiates peak acetylcholine-induced currents 6-fold relative to maximal acetylcholine, and slows channel desensitization, resulting in a 6900-fold increase in charge transfer. Decreases paw edema
in vivo
. Analgesic.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-160754 |
| Réf. fabricant | 18748356 |
| Nom chimique ou matériau | 3,4-Difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]benzenepropanamide |
| CAS | 2244989-34-0 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>24</sub>H<sub>26</sub>F<sub>2</sub>N<sub>6</sub>O |
| Pureté | 98% |
