Eplivanserin hemifumarate is a potent and selective 5-HT2A antagonist (IC50 values are 5.8 and 120 and >100 nM for 5-HT2A, 5-HT2B and 5-HT2C, respectively). Attenuates cocaine-induced hyperactivity. Increases dopamine (DA) release in rat medial prefrontal cortex (mPFC); potentiates haloperidol-induced DA release in the mPFC and nucleus accumbens.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-160771 |
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| Réf. fabricant | 18738218 |
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| Nom chimique ou matériau | (1Z,2E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime hemifumarate |
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| CAS | 130580-02-8 |
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| Synonyme | SR-46349 hemifumarate, SR-46349B |
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| Quantité | 10 mg |
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| Cible | 5-HT2A Receptor Antagonists |
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| Formule moléculaire | C<sub>19</sub>H<sub>21</sub>FN<sub>2</sub>O<sub>2</sub>.0.5C<sub>4</sub>H<sub>4</sub>O<sub>4</sub> |
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| Poids de la formule | 386.42 |
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| Pureté | >98% |
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