Sonidegib is a potent Smoothened (Smo) receptor antagonist (IC50 values are 1.3 nM and 2.5 nM at mouse and human receptors, respectively). Inhibits growth of a variety of tumor types including basal cell carcinoma, small cell lung cancer and medulloblastoma. Sonidegib inhibits Hh pathway in CD34+ chronic myeloid leukemia cells; it reduces both the number of cells and self-renewal ability. Brain penetrant and orally bioavailable.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-160805 |
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| Réf. fabricant | 18746926 |
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| Nom chimique ou matériau | rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide |
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| CAS | 956697-53-3 |
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| Quantité | 50 mg |
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| Cible | Smoothened |
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| Formule moléculaire | C<sub>26</sub>H<sub>26</sub>F<sub>3</sub>N<sub>3</sub>O<sub>3</sub> |
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