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STEMCELL Technologies Fumonisin B1 | B-LABO France
STEMCELL Technologies Fumonisin B1
Réf. : BL-RE-160886Réf. fabricant : 17130262 1 mg
180,90 € HT
Inhibitor of sphingolipid synthesis and protein serine/threonine phosphatases
CAS
116355-83-0
Quantité
1 mg
Formule moléculaire
C34H59NO15
Pureté
≥95%
Marque
STEMCELL Technologies
Caractéristiques principales
Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme that has been shown to potently inhibit sphingosine N-acyltransferase (ceramide synthase; Wang et al.), thereby disrupting the synthesis of sphingolipids, a key component of plasma membranes (IC50 = 0.1 μM)
Fumonisin B1 also inhibits protein serine/threonine phosphatases (PPs; PP1, PP2A, PP2B, PP2C, and PP5/T/K/H) with IC50 values of 80 - 3000 μM
PP5 is the most sensitive with an IC50 of 80 μM (Fukuda et al.) Fumonisin B1, together with aflatoxin B1, increases reactive oxygen species levels and oxidative damage in rat spleen cells (Mary et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-160886
Réf. fabricant
17130262
CAS
116355-83-0
Quantité
1 mg
Formule moléculaire
C<sub>34</sub>H<sub>59</sub>NO<sub>15</sub>
Pureté
≥95%
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