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Ref : p-7217435

182.25€ - 344.25€

HDR pathway enhancer; Enhances RAD51

CAS :

312756-74-4

Formule moléculaire :

C₂₀H₁₆Br₂N₂O₃S

Pureté :

≥95%

Brand

STEMCELL Technologies

Référence	Prix	Marque	Quantité	Add to cart
17180322	182.25€ - 344.25€	STEMCELL Technologies	25 mg
17170322	182.25€ - 344.25€	STEMCELL Technologies	10 mg

RS-1 is an enhancer of RAD51, an enzyme that assists in the homology-directed repair (HDR) pathway of DNA double-strand breaks, and is reported to function by stabilizing the active form of RAD51 and by enhancing recombinogenic activity of the enzyme (Jayathilaka et al.) Via this mechanism, RS-1 can stimulate HDR, thereby enhancing precise HDR-dependent CRISPR-Cas9 genome editing in some cell lines (Pinder et al.; Song et al.)
Promotes HDR, which is reported to enhance knock-in efficiency of CRISPR-Cas9 genome editing (Pinder et al.; Song et al.; however, these effects are cell type-specific and context-dependent (Xie et al.; Zhang et al.)
Stimulates the DNA-binding activity of RAD51 to promote cancer cell death and induce anti-tumor responses in a mouse xenograft tumor model (Mason et al.)

CAS : 312756-74-4

Formule moléculaire : C₂₀H₁₆Br₂N₂O₃S

Pureté : ≥95%

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