Caractéristiques principales
- STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that specifically suppresses STAT5 (IC50 = 47 μM) via binding to its SH2 domain
- It shows reduced potency towards the SH2 domains of STAT1, STAT3, or LCK (Müller et al.)
- Induces partial apoptosis of mature eosinophils at high concentrations (Schwartz et al.)
- Rescues IL-17 production in a proportion of restimulated TH17 clones (Zielinski et al.)
- Reduces growth of induced regulatory T cells (iTregs) in vitro (Betts et al.)
Caractéristiques techniques
| Marque | STEMCELL Technologies |
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| Réf. B-LABO | BL-RE-162439 |
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| Réf. fabricant | 17140282 |
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| CAS | 285986-31-4 |
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| Quantité | 5 mg |
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| Formule moléculaire | C<sub>16</sub>H<sub>11</sub>N<sub>3</sub>O<sub>3</sub> |
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| Pureté | ≥95% |
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