Bafilomycin B1 is a naturally occurring macrolide antibiotic that is produced by certain strains of Streptomyces bacteria.
Similar to other members of the bafilomycin family, Bafilomycin B1 has gained attention in the field of life sciences for its ability to selectively inhibit V-ATPase. This enzyme is responsible for maintaining the acidic pH in various cellular compartments, including lysosomes and endosomes. By inhibiting V-ATPase, it disrupts the acidification process within these compartments. This disruption can have profound effects on various cellular processes and pathways that rely on proper pH regulation, such as protein degradation, autophagy, and vesicular trafficking.
Due to its ability to modulate cellular pH and inhibit V-ATPase, Bafilomycin B1 has been widely used as a research tool to study the role of lysosomes, autophagy, and cellular homeostasis. It has been particularly useful in investigations related to autophagic flux, lysosomal degradation, and the interplay between autophagy and disease processes.
| Marque | Melford |
|---|---|
| Réf. B-LABO | BL-RE-163767 |
| Réf. fabricant | 30018089 |
| Nom chimique ou matériau | Bafilomycin B1 |
| CAS | 88899-56-3 |
| Formule moléculaire | C44H65NO13 |
| Quantité | 1 mg |
