"/> Tocris Bioscience™ ML T7 | B-LABO France

Tocris Bioscience™ ML T7

Name: Tocris Bioscience™ ML T7
Brand: Tocris Bioscience
SKU: 30042428
Price: 759.16 EUR
Availability: InStock

Réf. : BL-RE-164982Réf. fabricant : 30042428

759,16 € HT

Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3

Marque: Tocris Bioscience

ML T7 is a T cell immunoglobulin and mucin-containing molecule 3 (Tim-3) inhibitor; disrupts phosphatidylserine/CAECAM1 binding to Tim-3 (Kd = 7.0 μM and 7.4 μM for hTim-3 and mTim-3 respectively). ML T7 promotes cell proliferation, cytokine production and cytotoxicity of OT-I CD8+ cytotoxic T lymphocytes. ML T7 inhibits tumor growth in a syngeneic mouse model of hepatocellular carcinoma, increases NK cell tumor killing activity and DC maturation.