"/> Tocris Bioscience™ NRX 252114 | B-LABO France

Tocris Bioscience™ NRX 252114

Name: Tocris Bioscience™ NRX 252114
Brand: Tocris Bioscience
SKU: 30023129
Price: 222.46 EUR
Availability: InStock

Réf. : BL-RE-165005Réf. fabricant : 30023129 25 mg

222,46 € HT

Molecular glue Degrader of mutant β-catenin

Marque: Tocris Bioscience

NRX-252114 is a potent enhancer of the interaction between S37A mutant β-catenin, and its cognate E3 ligase, SCFβ-TrCP (EC50 = 6.5 nM; Kd = 0.4 nM). NRX-252114 is a molecular glue degrader that binds at the phosphoserine binding site on β-TrCP and induces mutant β-catenin ubiquitination and subsequent degradation.