"/> Tocris Bioscience™ T3 CLK | B-LABO France

Tocris Bioscience™ T3 CLK

Réf. : BL-RE-165017Réf. fabricant : 18734474 50 mg
1 057,21 € HT

Potent and selective pan-CLK inhibitor; also inhibits DYRK1A/B

Nom chimique ou matériau
4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
CAS
2109805-56-1
Quantité
50 mg
Cible
Cdc2-like Kinase Inhibitors
Formule moléculaire
C28H30N6O2
Marque
Tocris Bioscience

T3 CLK is a potent and selective pan CDC-like kinase (CLK) inhibitor (IC50 values are 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively). T3 CLK also inhibits DYRK1A/B (IC50 values are 230 nM and 260 nM for DYRK1B and DYRK1A, respectively in cellular assays). Exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3 CLK is cell permeable, stable and non-toxic.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-165017
Réf. fabricant18734474
Nom chimique ou matériau4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
CAS2109805-56-1
Quantité50 mg
CibleCdc2-like Kinase Inhibitors
Formule moléculaireC<sub>28</sub>H<sub>30</sub>N<sub>6</sub>O<sub>2</sub>
Pureté0.98
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