"/> Tocris Bioscience™ AZ 14145845 | B-LABO France

Tocris Bioscience™ AZ 14145845

Réf. : BL-RE-165035Réf. fabricant : 30067457 10 mg
281,85 € HT

Mer/Axl Dual inhibitor

Nom chimique ou matériau
3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine-6-methanamine
CAS
2830555-70-7
Quantité
10 mg
Cible
Additional RTK Inhibitors
Formule moléculaire
C32H35N9O
Marque
Tocris Bioscience

AZ 14145845 is a potent, and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively).

In vivo

, AZ 14145845 shows dose-dependent reduction of tumor growth in the Mer and Axl kinase Ba/F3 tumor xenograft model. AZ 14145845 combined with anti-PD1 antibodies and ionizing radiation increases survival in mice with MC38 tumors

in vivo

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-165035
Réf. fabricant30067457
Nom chimique ou matériau3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine-6-methanamine
CAS2830555-70-7
Quantité10 mg
CibleAdditional RTK Inhibitors
Formule moléculaireC<sub>32</sub>H<sub>35</sub>N<sub>9</sub>O
Pureté0.97
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