"/> Tocris Bioscience™ SB 24011 | B-LABO France

Tocris Bioscience™ SB 24011

Réf. : BL-RE-173351Réf. fabricant : 30241026 5 mg
276,45 € HT

Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

Nom chimique ou matériau
4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
CAS
1497415-41-4
Quantité
5 mg
Cible
Protein Dimerizers
Formule moléculaire
C34H38N4O7
Marque
Tocris Bioscience

SB 24011 is an inhibitor of STING-TRIM29 interaction (IC50 = 3.85 μM

in vitro

). SB 24011 binds to STING and inhibits TRIM29-E3 ligase interaction to increase cellular STING levels. In syngeneic mouse models, SB 24011 dose-dependently reduces CT26 and B16F10 tumor volumes when co-admistered with cGAMP .

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-173351
Réf. fabricant30241026
Nom chimique ou matériau4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
CAS1497415-41-4
Quantité5 mg
CibleProtein Dimerizers
Formule moléculaireC34H38N4O7
Pureté0.98
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