Tocris Bioscience™ SB 24011

Ref: 30241026
276.45

Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

Nom chimique ou matériau:
4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
CAS:
1497415-41-4
Quantité:
5 mg
Cible:
Protein Dimerizers
Formule moléculaire:
C34H38N4O7
Pureté:
0.98
Brand
Tocris Bioscience™
SB 24011 is an inhibitor of STING-TRIM29 interaction (IC50 = 3.85 μM in vitro). SB 24011 binds to STING and inhibits TRIM29-E3 ligase interaction to increase cellular STING levels. In syngeneic mouse models, SB 24011 dose-dependently reduces CT26 and B16F10 tumor volumes when co-admistered with cGAMP .

Nom chimique ou matériau : 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide

CAS : 1497415-41-4

Quantité : 5 mg

Cible : Protein Dimerizers

Formule moléculaire : C34H38N4O7

Pureté : 0.98

Similar items
Tocris Bioscience™ Janelia Fluor™ 646, Haloalkane 276.45
Tocris Bioscience™ Janelia Fluor™ 635, Haloalkane 276.45
Thermo Scientific Chemicals Imidaclopride 276.45
Thermo Scientific Chemicals Olaparib 276.45