"/> Tocris Bioscience™ BAY 593 | B-LABO France

Tocris Bioscience™ BAY 593

Name: Tocris Bioscience™ BAY 593
Brand: Tocris Bioscience
SKU: 30279880
Price: 330.44 EUR
Availability: InStock

Réf. : BL-RE-177665Réf. fabricant : 30279880

330,44 € HT

Geranylgeranyltransferase-I (GGTase-I) inhibitor

Marque: Tocris Bioscience

BAY 593 is a geranylgeranyltransferase-I (GGTase-I) inhibitor. Blocks activation of Rho-GTPases to inactivate YAP1/TAZ signaling. Dose-dependently inhibits growth of tumors in xenograft mouse models (IC50 values are 38.4 nM and 564 nM in MT-1080 and MDA-MB-231 cells respectively) and PXF 541 xenografts. Orally bioavailable and suitable for use

in vivo