Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as des-?-carboxy prothrombin (DCP), is an abnormal form of prothrombin produced primarily by liver tissues under conditions of vitamin K deficiency or antagonism. This immature prothrombin variant lacks sufficient coagulation activity and is prominently overexpressed in hepatocellular carcinoma (HCC) cells, serving as a crucial biomarker for screening and diagnosing HCC. PIVKA-II also appears in some cases of gastric cancer, albeit less frequently. Elevated serum levels of PIVKA-II are not exclusive to malignancies; they can also be seen in non-HCC conditions, which necessitates differential diagnostic strategies. The utility of PIVKA-II is further underscored by its ability to predict extrahepatic metastases in early HCC, supporting its role in comprehensive patient evaluation and monitoring.
- Numéro d’adhésion
- P00734
- Plage de dosage
- 0.16 to 10 ng/mL
- Sensibilité du dosage
- 0.09 ng/mL
- Conjugué
- HRP
- Type de produit
- ELISA
- Type d’échantillon
- Plasma, Serum
- À utiliser avec (équipement)
- Colorimetric Microplate Reader
- Identification génétique (Entrez)
- 2147
- Symbole de gène(s)
- F2
- Coefficient de variation inter-dosage
- <10
- Coefficient de variation intra-dosage
- <10
- Contenus des kits
- Micro ELISA Plate (Dismountable), Reference Standard, Concentrated Biotinylated Detection Ab(100x), Concentrated HRP Conjugate (100x), Reference Standard & Sample Diluent, Biotinylated Detection Ab Diluent, HRP Conjugate Diluent, Concentrated Wash Buffer(25x), Substrate Reagent, Stop Solution, Plate Sealer, Product Description, Certificate of Analysis
- Marqueur ou colorant
- Biotin
- Quantité
- 96 Tests
- État réglementaire
- RUO
- Volume d’échantillon
- Plasma: 100 μL, Serum: 100 μL
- Conditions de stockage
- Refer to product documentation for component specific storage temperature.
- Cible
- DCP
- Heure du test
- 1 hr. 20 min.
- Durée totale du dosage
- 3 hr. 30 min.
