The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.
- Numéro d’adhésion
- Q9NP85
- Plage de dosage
- 0.31 to 20 ng/mL
- Sensibilité du dosage
- 0.19 ng/mL
- Conjugué
- HRP
- Type de produit
- ELISA
- Type d’échantillon
- Plasma, Serum
- À utiliser avec (équipement)
- Colorimetric Microplate Reader
- Identification génétique (Entrez)
- 7827
- Symbole de gène(s)
- Nphs2
- Coefficient de variation inter-dosage
- <10
- Coefficient de variation intra-dosage
- <10
- Contenus des kits
- Micro ELISA Plate (Dismountable), Reference Standard, Concentrated Biotinylated Detection Ab(100x), Concentrated HRP Conjugate (100x), Reference Standard & Sample Diluent, Biotinylated Detection Ab Diluent, HRP Conjugate Diluent, Concentrated Wash Buffer(25x), Substrate Reagent, Stop Solution, Plate Sealer, Product Description, Certificate of Analysis
- Marqueur ou colorant
- Biotin
- Quantité
- 96 Tests
- État réglementaire
- RUO
- Volume d’échantillon
- Plasma: 100 μL, Serum: 100 μL
- Conditions de stockage
- Refer to product documentation for component specific storage temperature.
- Cible
- Podocin
- Heure du test
- 1 hr. 20 min.
- Durée totale du dosage
- 3 hr. 30 min.
