Mitomycin C is an antibiotic which acts as a double-stranded DNA alkylating agent
It covalently crosslinks DNA, inhibiting DNA synthesis and cell proliferation
It acts by way of reductive activation either through low pH or NAD(P)H:quinone oxidoreductase (DT-diaphorase) or NADH cytochrome c reductase (Mao et al.; Cummings et al.)
Mitotically inactivates mouse embryonic fibroblasts (MEFs) for use as feeder cell layers in embryonic stem cell co-culture systems (Bryja et al.)
Selectively inhibits DNA synthesis and mutagenesis, stimulates genetic recombination, chromosome breakage and sister chromatid exchange, and induces DNA repair (Tomasz)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-078415
Réf. fabricant
17190192
CAS
50-07-7
Pourcentage de pureté
≥98%
Quantité
10 mg
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