Nicotinamide (NAM) is a cell culture supplement used in the differentiation of embryonic stem (ES) and induced pluripotent stem (iPS) cells
It is an amide derivative of vitamin B3, a poly (ADP-ribose) polymerase (PARP) inhibitor, and represents the primary precursor of NAD+
Nicotinamide has also been shown to modulate stem cell differentiation in various applications, most notably for the differentiation of pancreatic mouse ES and iPS cells to pancreatic islet-like insulin-secreting cells
