For the development of sandwich ELISAs to measure natural and recombinant mouse Leukemia Inhibitory Factor (LIF)
Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts. The activities of LIF are mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an alpha subunit (LIF R alpha, also known as LIF R beta and CD118) that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex.
| Marque | R&D Systems |
|---|---|
| Réf. B-LABO | BL-RE-098486 |
| Réf. fabricant | 30001776 |
| Quantité | 1 Kit |
| Espèces | Mouse |
| Conjugué | Biotin |
| Cible de liaison | LIF |
| Plage de dosage | 6.25 to 400 pg/mL |
| À utiliser avec (application) | ELISA |
| Identification génétique (Entrez) | 3976 |
| Synonyme | CDF, D factor, DIA, differentiation inhibitory activity, differentiation stimulating factor, Differentiation-stimulating factor, Emfilermin, HILDA, HILDAcholinergic differentiation factor, leukemia inhibitory factor, leukemia inhibitory factor (cholinergic differentiation factor), Melanoma-derived LPL inhibitor, MLPLI |
| Contenu et stockage | Store the unopened product at 2°C to 8°C. Do not use past expiration date. |
