ZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices
in vitro
. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration
in vivo
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-104831 |
|---|
| Réf. fabricant | 18045592 |
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| Pureté | 95% |
|---|
| Contenu et stockage | Store at -20°C |
|---|
| Poids moléculaire | observed_molecular_weight: 1928.4 |
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| Quantité | 1 mg |
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