Highly selective and potent CRF2 antagonist
K 41498 is a potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats
in vivo
, blocks urocortin-induced hypotension following systemic administration.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-104832 |
| Réf. fabricant | 18045172 |
| Pureté | 95% |
| Contenu et stockage | Store at -20°C |
| Quantité | 1 mg |
