Used for Func, SDS-PAGE
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq]
| Marque | Abnova |
|---|---|
| Réf. B-LABO | BL-RE-105302 |
| Réf. fabricant | 16058076 |
| À utiliser avec (application) | Functional Study, SDS-PAGE |
| Formule | In 20mM Tris-HCl, 500mM NaCl, 1mM CaCl |
| Identification génétique (Entrez) | 290 |
| Poids moléculaire | 110-130kDa |
| Nom | ANPEP (Human) Native Protein |
| Méthode de préparation | Native protein purified from human serum |
| Méthode de purification | Saltprecipitation/Ion Exchange Chromatography/Gelfiltration |
| Test du contrôle qualité | 15% SDS-PAGE Stained with Coomassie Blue |
| Quantité | 10 ug |
| Conditions de stockage | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
| État réglementaire | RUO |
| Alias de gène | APN/CD13/LAP1/PEPN/gp150/p150 |
| Nom usuel | ANPEP |
| Symbole de gène(s) | ANPEP |
| Activité biologique | > 500mU/mg (L-Leu-pNA at 37°C, pH 7.2). |
| Espèces | Human |
| Marqueur de protéine | None |
| Système d’expression | Native protein purified from human serum |
| Forme | Liquid |
| Pureté ou qualité | >90% by SDS-PAGE |
