The type I interferons, IFN-alpha and IFN-beta, are a group of structurally and functionally related proteins that are induced by either viruses or double-stranded RNA and are defined by their ability to confer an antiviral state in cells. IFN-alpha and IFN-beta appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN-gamma) binds to a distinct receptor. This distinct receptor, IFN-alphaR, is only weakly responsive to type I interferons, in contrast to IFN-alpha/betaR, which binds to and responds effectively to IFN-beta and to several of the IFN-alpha subtypes. IFN-alpha/betaR is expressed as two alternatively spliced transcripts, designated IFN-alpha/betaRalpha (IFN-alpha/betaR1) and IFN-alpha/betaRbeta (IFN-alpha/betaR2), both of which are involved in signal transduction and ligand binding.
Caractéristiques techniques
| Marque | Invitrogen |
|---|
| Réf. B-LABO | BL-RE-106520 |
|---|
| Réf. fabricant | 18557864 |
|---|
| Numéro d’adhésion | AI747302; human interferon alpha/beta receptor; IFN alpha/betaRbeta; IFN R2; IFNABR; IFNalpha/beta R2; IFN-alpha/beta receptor 2; IFNalpha/betaR2; IFN-alpha/betaR2; IFN-alpha/betaRbeta; IFNalpha/beta-Rbeta; IFN-alpha-REC; IFNAR2; Ifnar-2; IFNARB; IFN-R; IFNR2; IFN-R-2; IMD45; interferon (alpha and beta) receptor 2; interferon (alpha, beta and omega) receptor 2; interferon alpha and beta receptor subunit 2; interferon alpha binding protein; Interferon alpha/beta receptor 2; interferon receptor 2 c; interferon-alpha/beta receptor 2; interferon-alpha/beta receptor beta chain; type I interferon alpha/beta receptor 2 A; Type I interferon receptor 2 |
|---|
| Plage de dosage | 0.25 to 50 ng/mL |
|---|
| Sensibilité du dosage | 0.25 ng/mL |
|---|
| Conjugué | Biotin |
|---|
| Type de produit | ELISA |
|---|
| Type d’échantillon | Plasma |
|---|
| À utiliser avec (équipement) | Colorimetric Microplate Reader |
|---|
| Identification génétique (Entrez) | O35664 |
|---|
| Symbole de gène(s) | IFNAR2 |
|---|
| Coefficient de variation inter-dosage | <12% |
|---|
| Coefficient de variation intra-dosage | <10% |
|---|
| Contenus des kits | Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers |
|---|
| Marqueur ou colorant | HRP |
|---|
| Quantité | 10 x 96 Tests |
|---|
| État réglementaire | Research Use Only |
|---|
| Volume d’échantillon | Serum, 50 µL; Plasma, 50 µL; Supernatant, 50 µL |
|---|
| Conditions de stockage | 2°C to 8°C |
|---|
| Cible | IFNAR2 |
|---|
| Heure du test | 1 hr 20 min |
|---|
| Durée totale du dosage | 4 hr 45 min |
|---|
Une question, une configuration particulière ?
Contactez-nous pour un devis.
