Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
Caractéristiques techniques
| Marque | Invitrogen |
|---|
| Réf. B-LABO | BL-RE-106537 |
|---|
| Réf. fabricant | 18527814 |
|---|
| Numéro d’adhésion | AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341 |
|---|
| Plage de dosage | 0.2 to 50 ng/mL |
|---|
| Sensibilité du dosage | 0.2 ng/mL |
|---|
| Conjugué | Biotin |
|---|
| Type de produit | ELISA |
|---|
| Type d’échantillon | Supernatant |
|---|
| À utiliser avec (équipement) | Colorimetric Microplate Reader |
|---|
| Identification génétique (Entrez) | Q9JI71 |
|---|
| Symbole de gène(s) | Dll4 |
|---|
| Coefficient de variation inter-dosage | <12% |
|---|
| Coefficient de variation intra-dosage | <10% |
|---|
| Contenus des kits | Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers |
|---|
| Marqueur ou colorant | HRP |
|---|
| Quantité | 10 x 96 Tests |
|---|
| État réglementaire | Research Use Only |
|---|
| Volume d’échantillon | Serum, 50 µL; Plasma, 50 µL; Supernatant, 50 µL |
|---|
| Conditions de stockage | 2°C to 8°C |
|---|
| Cible | DLL4 |
|---|
| Heure du test | 1 hr 20 min |
|---|
| Durée totale du dosage | 4 hr 45 min |
|---|
Une question, une configuration particulière ?
Contactez-nous pour un devis.
