Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor
ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) . Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124372 |
| Réf. fabricant | 18045892 |
| Nom chimique ou matériau | N-[[[(1 S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid |
| CAS | 723331-20-2 |
| Quantité | 10 mg |
| Solubilité | Soluble to 100mM in DMSO |
| Cible | Carboxypeptidase Inhibitors |
| Formule moléculaire | C<sub>12</sub>H<sub>20</sub>N<sub>2</sub>O<sub>7</sub> |
| Poids de la formule | Observed MW: 304.3 |
| Pureté | 95% |
