ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) . Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.
- Nom chimique ou matériau
- N-[[[(1 S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid
- CAS
- 723331-20-2
- Quantité
- 10 mg
- Solubilité
- Soluble to 100mM in DMSO
- Cible
- Carboxypeptidase Inhibitors
- Formule moléculaire
- C12H20N2O7
- Poids de la formule
- Observed MW: 304.3
- Pureté
- 95%
