"/> Tocris™ dTAGV-1 | B-LABO France

Tocris™ dTAGV-1

Réf. : BL-RE-124389Réf. fabricant : 18707736 5 mg
548,58 € HT

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Nom chimique ou matériau
(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-((-1-((2 S,4 R)-4-hydroxy-2-((-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl -1-(-2-(3,4,5-trimethoxyph)
Quantité
5 mg
Cible
TAG Degradation Platforms
Formule moléculaire
C68H90N6O14S CF3CO2H
Pureté
0.98
Marque
Tocris

dTAGV-1 is a degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand. Induces potent and selective degradation of FKBP12F36V fusion proteins

in vitro

in vivo

. Selectively degrades FKBP12F36V-EWS/FLI fusion proteins and inhibits cell proliferation in FKBP12F36V-EWS/FLI-expressing Ewing sarcoma cells. Hydrochloride salt (Cat.No. 7374) available; suitable for

Caractéristiques techniques

MarqueTocris
Réf. B-LABOBL-RE-124389
Réf. fabricant18707736
Nom chimique ou matériau(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-((-1-((2 S,4 R)-4-hydroxy-2-((-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl -1-(-2-(3,4,5-trimethoxyph)
Quantité5 mg
CibleTAG Degradation Platforms
Formule moléculaireC<sub>68</sub>H<sub>90</sub>N<sub>6</sub>O<sub>14</sub>S CF<sub>3</sub>CO<sub>2</sub>H
Pureté0.98
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