XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells
in vitro
and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-124415 |
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| Réf. fabricant | 18740298 |
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| Nom chimique ou matériau | 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride |
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| CAS | 1169562-71-3 |
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| Quantité | 10 mg |
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| Solubilité | Soluble to 20mM in water |
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| Formule moléculaire | C<sub>14</sub>H<sub>12</sub>ClN<sub>3</sub>O<sub>2</sub>.HCl |
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| Poids de la formule | Observed MW: 326.18 |
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| Pureté | >99% |
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