"/> Tocris Bioscience™ Indinavir sulfate | B-LABO France

Tocris Bioscience™ Indinavir sulfate

Réf. : BL-RE-124511Réf. fabricant : 18738976 50 mg
157,66 € HT

Potent and selective HIV-1 and HIV-2 protease inhibitor

Nom chimique ou matériau
2,3,5-Trideoxy-N-[(1 S,2 R)-2,3-dihydro-2-hydroxy-1 H-inden-1-yl]-5-[(2 S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate
CAS
157810-81-6
Quantité
50 mg
Cible
HIV Protease Inhibitors
Formule moléculaire
C36H47N5O4.H2SO4
Marque
Tocris Bioscience

Indinavir sulfate is a potent and selective HIV protease inhibitor (Ki values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes.

In silico

docking models predict potential as an inhibitor of SARS-CoV-2 3CLpro.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-124511
Réf. fabricant18738976
Nom chimique ou matériau2,3,5-Trideoxy-N-[(1 S,2 R)-2,3-dihydro-2-hydroxy-1 H-inden-1-yl]-5-[(2 S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate
CAS157810-81-6
Quantité50 mg
CibleHIV Protease Inhibitors
Formule moléculaireC<sub>36</sub>H<sub>47</sub>N<sub>5</sub>O<sub>4</sub>.H<sub>2</sub>SO<sub>4</sub>
Pureté0.98
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