NADPH oxidase (Nox) inhibitor
VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC50 = 2 μM). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs
in vitro
. Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF-β-induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124513 |
| Réf. fabricant | 18739126 |
| Nom chimique ou matériau | 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine |
| CAS | 722456-31-7 |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>18</sub>H<sub>12</sub>N<sub>6</sub>OS |
| Poids de la formule | 360.39 |
| Pureté | 98% |
