"/> Tocris Bioscience™ AZ 13824374 | B-LABO France

Tocris Bioscience™ AZ 13824374

Réf. : BL-RE-124526Réf. fabricant : 18709336 2 mg
370,40 € HT

Potent and selective ATAD2 bromodomain inhibitor

Nom chimique ou matériau
(1R,2R,5S)-11-(8-((1-(2-Fluoro-2-methylpropyl)piperidin-4-yl)amino)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl)-2-isopropyl-2,3,5,6-tetrahydro-1,5-epiminobenzo[d]azocin-4(1H)-one
Quantité
2 mg
Cible
ATAD2
Formule moléculaire
C30H39FN8O2
Marque
Tocris Bioscience

AZ 13824374 is a potent and selective inhibitor of ATPase family AAA domain-containing protein 2 (ATAD2) bromodomain (pIC50 values are 6.2 and 8.2 in NanoBRET assay and FRET assay, respectively). It is >100-fold selective over a range of epigenetic targets from ROMO

scan

panel (DiscoveRx Corp.). AZ 13824374 shows cellular target engagement (cellular inhibition pIC50 = 6.9) and antiproliferative activity in a range of breast cancer cell lines.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-124526
Réf. fabricant18709336
Nom chimique ou matériau(1R,2R,5S)-11-(8-((1-(2-Fluoro-2-methylpropyl)piperidin-4-yl)amino)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl)-2-isopropyl-2,3,5,6-tetrahydro-1,5-epiminobenzo[d]azocin-4(1H)-one
Quantité2 mg
CibleATAD2
Formule moléculaireC<sub>30</sub>H<sub>39</sub>FN<sub>8</sub>O<sub>2</sub>
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