AZD 9272 is a potent and selective mGlu5 antagonist (IC50 values are 2.6 and 7.6 nM for rat and human receptors, respectively). Exhibits >3900-fold selectivity for mGlu5 over other mGlu receptors. Also selective over a panel of other targets. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.
- Nom chimique ou matériau
- 3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
- CAS
- 327056-26-8
- Quantité
- 50 mg
- Cible
- Group I mGluR Antagonists
- Formule moléculaire
- C14H6F2N4O
- Poids de la formule
- 284.22
- Pureté
- >98%
